張力天的資訊網頁

論文與著作 Papers and Publications
期刊 Journal
篇名 下載
1

Cicero Lee-Tian CHANG and Hang-Poung FUNG. Effects of Ketoconazole onProgesterone and cAMP Production in MA-10 Mouse Leydig Tumor Cells. Biol. Pharm.Bull., 2002(25):794-797.  (SCI; Parmacology & Pharmacy:170/261; impact factor: 1.657)

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2 Chang Cicero LT, Kuo HK, Chang SL, Chiang YM, Shyur LF, Yang WC. The distincteffects of a butanol fraction of Bidens pilosa plant extract on the development ofTh1-mediated diabetes and Th2-mediated airway inflammation in mice. J Biomed Sci2005(12): 79-89. (SCI; Medicine, Research & Experimental 61/111; impact factor: 1.980) download
3 張力天、馮翰鵬、林永富、陳三多. 2002. Indenopyridine Hydrochloride 抑制Sprague-Dawley大鼠睪丸造精作用及引起造精細胞之病理變化。台灣獸醫誌。28(4):294-300.
4 Chang, S.L., Chang, C. L. T.,Chiang, Y.M., Hsieh, R. H., Tzeng, C.R., Wu, T. K.,Sytwu, H. K., Yang, N. S., Shyur L.F., Yang, W.C. Polyacetylenic Compounds andButanol Fraction from Bidens pilosa can modulate the differentiation of helper T cellsand prevent autoimmune diabetes in non-obese diabetic mice. Planta med 2004(70):   1045-1051. (SCI; Chemistry, Medicinal: 31/59;  Plant Science: 56/190; Pharmacology & pharmacy: 130/261; impact factor: 2.513) download
5

Cicero Lee-Tian Chang*, Hang-Poung Fung, Yung-Fu Lin, Ching-Yang Kuo, and Chi Wei Chien. Indenopyridine Hydrocholoride Induced Testicular Spermatogenesis Failure with High Seminal Alkaline Phosphatase Levels in Male Dog. Biol. Pharm. Bull. 2002(25): 1097-1100.

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6 Chiang YM, Chang Cicero LT, Chang SL, Yang WC, Shyur LF. Cytopiloyne, a novelpolyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. J.Ethnopharm. 2007(110):532-538. (SCI; Integrative & Complentary Medicine; 4/22; Chemistry, medicinal: 20/59; pharmacology & pharmacy: 78-261; plant science: 31/190; impact factor: 3.014 ) download
7 Chang Cicero LT, Chang SL, Lee YM, Chiang YM, Chuang DY, Kuo HK, YangWC. Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Non-obeseDiabetic Mice. Journal of Immunology. 2007(178):6984-6993. (SCI; Immunology; 20-139; impact factor: 5.788) download
8 Chang SL, Chiang YM, Chang Cicero LT, Yeh HH, Shyur LF, Kuo YH, Wu TK, Yang WC. Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulateIFN-gamma expression. Journal of Ethnophamacology. 2007(112):232-236.  (SCI; Integrative & Complentary Medicine; 4/22; Chemistry, medicinal: 20/59; pharmacology & pharmacy: 78-261; plant science: 31/190; impact factor: 3.014 ) download
9 Yi-Jou Hsua, Tsung-Han Lee, Cicero Lee-Tian Chang, Yuh-Ting Huangc,Wen-Chin Yang. Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract. Journal of Ethnopharmacology. 2009(122):379-383,  (SCI; Integrative & Complentary Medicine; 4/22; Chemistry, medicinal: 20/59; pharmacology & pharmacy: 78-261; plant science: 31/190; impact factor: 3.014 ) download
10 Chang SL, Chang CL, Huang PI, Tao MH, Yang WC. Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity. Molecular Immunolgoy. 2009, 46:3218-3223 (SCI; Immunology; 74-139; biochemistry & molecular biology: 137/289 impact factor: 2.897) download
11 Tzu-Hsuan Li, Chia-Chung Hou, Cicero Lee-Tian Chang , and Wen-Chin Yanga, Anti-hyperglycemic properties of crude extract and triterpenes from Poria cocos. Evidence-Based Complementary and Alternative Medicine. 2010:1-8, (SCI; INTEGRATIVE & COMPLEMENTARY MEDICINE; 1/22; impact factor:4.774)(Corresponding author) download
12 1.       Shen MY, Lin YP, Yang BC, Jang YS,  Chiang CK, Clément Mettling, Chen ZW, Sheu JR, Chang Cicero LT, Lin YL, and Yang WC. 2011 Catenarin prevents type 1 diabetes in non-obese diabetic mice via inhibition of leukocyte migration involving the MEK6/p38 and MEK7/JNK pathways. Evid Based Complement Alternat Med. 2012:1-13(SCI; INTEGRATIVE & COMPLEMENTARY MEDICINE; 1/22; impact factor:4.774)(Corresponding author) download
13 Liu HY, Chung CY, Yang WC, Liang CL, Wang CY, Chang CY, Chang Cicero LT. 2011. Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice. J Vet Sci. 2012(13):245-252 (SCI: VETERINARY SCIENCES: 46/143; impact factor:1.161)(Corresponding author) download
14

Patent: Polyacetylenic compounds (European)

 

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15 Shen MY, Liu YJ,  Don MJ, Liu HY, Chen ZW, Clément Mettling, Pierre Corbeau, Chiang CK, Jang YS, Li TH, Paul Young, Chang Cicero LT, Lin YL, Yang WC. Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica. PLOS one 2011(6):e27480- (SCI; Biology: 12/84; impact factor:4.092) download
16

Butanol extract of Bidens pilosa

Patent No: US 8048800 B2

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17 Patent: Polyacetylenic compounds (USA) download
18 Wen-Li Hsu, Pei-Jung Chung, Ming-Hsien Tsai, Cicero Lee-Tian Chang, Chih-Lung Liang. A Role for Epstein-Barr Viral BALF1 in Facilitating Tumor Formation and Metastasis Potential. Virus Research 2011(163):617-627 (SCI; VIROLOGY:16/32; impact factor:2.941) download
19 Hsien-Yueh LIU, Shiun-Long LIN, Bing-Qi HUANG, Wei-Ya CHANG, Chi-Young WANG, * Cicero Lee-Tian CHANG. Analysis of the Expression of CD45, CD11b and NSA of Blood
Cells in Healthy and Tumor-bearing Dogs by Flow Cytometry. Taiwan Vet J2012, 38 (4): 233-242.
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20 C.L.T. Chang, Yi-Ching Chen, Hui-Ming Chen, Ning-Sun Yang and Wen-Chin Yang*. Natural Cures for Type 1 Diabetes: A Review of Phytochemicals, Biological Actions, and Clinical Potential. Current Medicinal Chemistry, 2013(20):899-907 download
21 Cicero Lee-Tian Chang, Hsien-Yueh Liu, Tien-Fen Kuo, Yi-Jou Hsu, Ming-Yi Shen, Chien-Yuan Pan, and Wen-Chin Yang. Antidiabetic Effect and Mode of Action of Cytopiloyne. Evid Based Complement Alternat Med. 2013:1-13. download
22 Cicero L. T. Chang, Yenshou Lin, Arlene P. Bartolome, Yi-Ching Chen, Shao-Chih Chiu,
Wen-Chin Yang. Herbal therapies for type2 diabetes mellitus: Chemistry, biology and potential application of selected plants and compounds. Evid Based Complement Alternat Med. Article 2013, ID 378657, 33 pages
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23 Patent: 咸豐草之正丁醇萃取物 (I347191) download
24 Patent: 聚炔類化合物(I370737) download
25

Patent: 抑制白血球之cxc 趨化素受器4 型之虎杖萃取
物之製造方法 (I422383)

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26

W.C. Yang, Y.J. Tien, C.Y. Chung, Y.C. Chen,W.H. Chiou, S.Y. Hsu, H.Y. Liu,
C.L. Liang, C.L.T. Chang*.  Effect of Bidens pilosa on infection and drug resistance of Eimeria in chickens. Research in Veterinary Science 2015(98):74-81.

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27

Bun-Yueh Lai, Tzung-Yan Chen, Shou-Hsien Huang, Tien-Fen Kuo,
Ting-Hsiang Chang, Chih-Kang Chiang, Meng-Ting Yang, and Cicero Lee-Tian Chang. Bidens pilosa Formulation Improves Blood Homeostasis and 𝛽-Cell Function in Men: A Pilot Study. Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 832314, 5 pages

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28

第二型糖尿病 ─老疾病的新治療契機

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29

小草也可以立大功 ─從含抗生素茶葉蛋的新聞談起

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30

Cicero L. T. Chang, Chih-Yao Chung, Chih-Horng Kuo, Tien-Fen Kuo, Chu-
Wen Yang, Wen-Chin Yang. Beneficial Effect of Bidens pilosa on Body
Weight Gain, Food Conversion Ratio, Gut Bacteria and Coccidiosis in Chickens. PLoS ONE 11(1): e0146141.

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31

Chih-Yao Chung, Wen-Chin Yang, Chih-Lung Liang, Hsien-Yueh Liu, Shih-Kai Lai, Cicero Lee-Tian Chang. Cytopiloyne, a polyacetylenic glucoside from Bidens pilosa, acts as a novel anticandidal agent via regulation of macrophages. Journal of Ethnopharmacology, 2016(184):72–80.

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32

Chih-Yao Chung, Wen-Chin Yang, Chih-Lung Liang, Hsien-Yueh Liu, Shih-Kai Lai, Cicero Lee-Tian Chang.  Data on the effect of Cytopiloyne against Listeria monocytogenes infection in mice. Data in Brief 7 (2016) 995–998.

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33

Cicero Lee-Tian Chang, Cheng-Ying Yang, Thangarasu Muthamilselvan & Wen-Chin Yang. Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers. Scientific Reports | 6:24692 | DOI: 10.1038/srep24692

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34

Yu-Chuan Liang, Meng-Ting Yang, Chuan-Ju Lin, Cicero Lee-Tian Chang and Wen-Chin Yang. Bidens pilosa and its active compound inhibit and adipogenesis and lipid accumulaiton via down-modulation of the C/EBP and PPARr pathways. Scientific Reports, 2016, srep24285

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論文發表 Dissertation
篇名 下載
1    張力天2002Ketoconazole影響雄畜睪丸類固醇生合成作用之研究,博士論文。

國內、外研討會 Seminar
篇名 下載
1

11\2000 : 11th Congress of the Federation of Asian Veterinary Associations

題目: Effect of Ketoconazole Treatment on Testosterone Response to Human Chorionic Gonadotropin Stimulation in Male Dogs

2

5\2001: 台灣畜牧獸醫學會九十年度春季學術研討會                        

題目: Indenopyridine Hydrochloride對公犬造精作用之影響

3

5\2001: 台灣畜牧獸醫學會九十年度春季學術研討會                         

題目:Effect of Ketoconazole Treatment on Testosterone and LH Response to GnRH Stimulation in Male Dogs

4

1\2002:中華民國實驗動物學會第七屆第二次會員大會暨學術研討會(台北)

題目:Indenopyridine Hydrochloride 對公犬藥物性絕育之研究

5 5\2002:台灣省畜牧獸醫學會九十一年度春季學術研討會(台中)題目:Indenopyridine Hydrochloride 對犬及大鼠造精作用之抑制
6

1\2003: 3rd IBS Poster Competition, Academia Sinica                     

題目:Characterization of bio-active phytocompounds via the screening platforms composed of T cells and autoimmune mouse models

7

2003: ASOMPS XI-2003; 11th Asian Symposium on    Medicinal Plants, Spices and other Natural Products (昆明)

: Utilizing autoimmune mouse models to confirm immunomodulatory bioactivity of in vitro screened phytocompounds.

8

1\2004: 4th IBS Poster Competition, Academia Sinica (第一名)

題目:Polyacetylenic glucoside and butanol fraction from Bidens pilosa can prevent non-obese diabetes via regulating CD4+ T cell differentiation and conferring an ability of cells to kill CD4+ T cells

9

7\2004: 10th SCBA International Symposium (Peijing)            

題目:Polyacetylenic glucoside and butanol fraction from Bidens pilosa can prevent non-obese diabetes via regulating CD4+ T cell differentiation and conferring an ability of b cells to kill CD4+ cells (Travel fund)

10

2\2005: 5th IBS Poster Competition, Academia Sinica      

題目:Using cytopiloyne from Bidens pilosa to prevent non-obese diabetes (第二名)

11

12\2007: 中華民國獸醫學會暨台灣省畜牧獸醫學會96年度聯合年會暨學術論文發表會議程 (台中市)

題目: 發展改善糖尿病草藥的經驗

         Experience on Development of ANti-diabetic Herb Medicine

12 Huang, Y.T., Hsu, Y.J., Chang, C.L.T, Lee, T.H., and Yang, W.C.* (2008) Evaluation of Bidens pilosa water extract as a food supplement for type 2 diabetes. ICPM2008 and 5th International Conference on Plant Metabolomics, Yokohama, Japan, p232
13  Hsu, Y.J., Chang, C.L.T, and Yang, W.C.* (2008) Anti-diabetic effects of cytopiloyne in db/db mice and its likely mechanism. ICPM2008 and 5th International Conference on Plant Metabolomics, Yokohama, Japan, p177 download
14 張力天 2009 天然物與糖尿病 2009 May 1st 中山醫學大學 醫學應用微生物所  
15 Wen-Chin Yang, Yi-Jou Hsu, Tsung-Han Lee, Cicero Lee-Tian Chang. (2009) Anti-diabetic effects and mechanism of Bidens Pilosa water extract. MSDA 6th Metabolic syndrome, type II Diabetes and Atherosclerosis Congress, Berlin, German, p78
16 Hsu, Y.J., Chang, C.L.T., Chiang, Y.M., Yang, W.C. (2009) Research and development of Bidens pilosa as an anti-diabetic nutraceutical and phytomedicine. 12th SCBA international symposium. P253
17 Hsu, Y.J., Lee, T.H., Chang, C.L.T., Chiang, Y.M., Yang, W.C. Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract (2009) 12th SCBA international symposium. P252
18

2010/04/07:兩岸獸醫學術交流會議(北京/中國農業大學)

演講題目:以天然萃取物研究巨噬細胞及脂肪細胞的脂質代謝

19

2010/06/23:上海中國科学院上海藥物研究所

演講題目:Effect and mechanism of Bidens pilosa and its active compound, cytopiloyne,
for Type 1 diabete
(研發咸豐草預防與治療第一型糖尿病)

20

2010/06/29:香港浸會大學賽馬會中藥研究院/生物資訊中心

題目:Evidence-based research and development of herbal medicine for type 1 diabetes
(研發預防與治療第一型糖尿病的植物藥)

21  
2010/08/23 日本神戶(Kobe) 14th International Congress of Immunology
演講題目:Prophylactic effect and mechanistic study of cytopiloyne, a plant polyacetylene, on type 1 diabetes in non-obese diabetes mice
22

2012/10/12-16 中國上海 The Third International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases

題目: Immune intervention of type 1 diabetes by targeting T cell subsets in murine models

23

2012/10/17-22中國北京市中國中醫科學院中醫臨床基
礎醫學研究所移地研究

專題討論:一個獸醫做傳統醫學研究(Veterinary Viewpoint on the Study of Traditional Medicine)

24

2013/07/19-22 中國西安  The 14th SCBA Internationl Symposium

題目: Cicero Lee-Tian Chang, Shou-Hsien Huang, Tien-Fen Kuo, and Wen-Chin Yang.

Mechanistic study and target identification of a novel anti-diabetic pytocompound, cytopiloyne

25

2013/12/2-6 澳洲墨爾本 

2013 IDF

The World Diabetes Congress

Poster: Mechanistic study and target identification of an anti-diabetic compound, cytopiloyne 


其他 Others
篇名 下載
1

參予計劃:

1. 7\ 1\2002- 6\30\2005: Bio-activity/efficacy study to evaluate innate/cell-mediated immunity responsive to medicinal herbs.                 

NSC89-2000-A-002-001 (NSC91-3112-P-001-035-Y)(國科會)      

2. 1\ 1\2005- 12\31\2007: Study on the role of a novel polyacetylrnic glycoside, BPB 3-3a, in T cell-mediated immunity and its application in non-obese diabetes treatment.                   

NSC89-2000-A-002-001(國科會)

3. 1\1\2008- 12\31\2008: 大花咸豐草純萃取物 cytopiloyne 抑制脂肪代謝及其機制探討                    Mechanism of inhabition on adipogenesis by cytopiloyne frome Bidens pilosa

TCVGH-NCHU 977607 (97年度榮興計劃) 

4. 1\1\2008- 12\31\2008: 結合獸醫醫療精進案與獸醫師法修正草案                     Linkage of Advanced Veterinary Medicine Courses to Modified Law of Governing Veterinarian97

農科-14.6.1--B7 (97AS-14.6.1-BQ-B7) (農委會施政計畫) 

5. 1\1\2008- 12\31\2008: 以天然萃取物研究巨噬細胞及脂肪細胞的交替功能及生理影響

CC97118 中興大學97年度全面提昇學術領域計畫 

6. 2008/08/01 ~ 2011/07/31: cytopiloyne 抗胰島細胞凋零的機制及開發胰島移植相關藥物                       Anti-apoptotic mechanism of cytopiloyne on islet cells and development of drugs on islet graft transplantation

97-2320-B-005-001-MY3 (國科會專題研究計畫)

7.2009/1/1 2009/12/31

以天然萃取物及PPAPγ 配體研究GATA-3 在脂質代謝的角色

(中興大學98年度全面提昇學術領域計畫)

8. 2009/1/1 2009/12/31

結合獸醫醫療精進案與獸醫師法修正草案(2)

98AS-9.6.2-BQ-B1(Z)

9. 2009/7/12010/2/28

(1)以大花咸豐草萃取物cytopiloyne探討GATA-3在脂質新生機制中扮演的角色

(2)糖尿病治療藥物Exendin-4對於糖尿病小鼠巨噬細胞廓清病原菌之相關研究

國科會大專生計畫

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2

1.獸醫師國家檢覈考試及格

2.原子能委員會醫用游離輻射防護講習班及格             

    ( 2\1993獲操作執照)

3.獸醫專門職業及技術人員高等考試及格

4.獸醫全國性公務人員高等考試及格

5.管制藥物使用執照

6.1 \2001 British Small Animal Veterinary Association會員

7.實驗動物飼養管理訓練課程結業

 

3 「研發抗雞隻球蟲之咸豐草配方」獲得第十屆國家新創獎學研組獎項 download


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姓名
張力天
職稱
教授
系所
獸醫學系
電話
886-4-22840894 ext 608
郵件
ltchang@nchu.edu.tw
傳真
886-4-22862073
辦公室
886-4-22840894 ext 608