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Metabolic Pathways Enhancement Confers Poor Prognosis in P53 Exon Mutant Hepatocellular Carcinoma.    
Chen PM, Li JR, Liu CC, Tang FY, Chiang EI*   
 2020 Jan 7;19:1176935119899913. doi: 10.1177/1176935119899913. eCollection 2020.
PMID: 31933519
MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S-adenosylmethionine and de novo purine synthesis. (IF=5.22)
Wang YC, Wu MT, Tang FY, Chen DY, Ko HA, Shane B, Huang WN, Chiang EP*.
Clin Sci (Lond). 2019 Jan 25;133(2):253-267. doi: 10.1042/CS20180932. Print 2019 Jan 31.
N-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo. (IF=4.668)
Chiu SC, Chao CY, Chiang EI*, Syu JN, Rodriguez RL, Tang FY.
J Nutr Biochem. 2017 Jan 28;42:172-181. doi: 10.1016/j.jnutbio.2017.01.009.
PMID: 28189115
Impact of diet-derived signaling molecules on human cognition : exploring thr food-brain axis .
Rodriguez RL, Albeck JG, Taha AY, Ori-Mckenney KM, Recanzone GH, Stradleigh TW, Hernandez BC, Tang FV, Chiang EI* , Cruz-Orengo L.      
 2017 Oct 30;1:2. doi: 10.1038/s41538-017-0002-4. eCollection 2017.
PMID: 31304244
S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis.    
Syu JN, Yang MD, Tsai SY, Chiang EI* , Chiu SC, Chao CY, Rodriguez RL, Tang FY.      
 2017 Oct;26(10):1636-1647. doi: 10.1177/0963689717724792.
PMID: 29251114
Dual inhibition of key proliferation signaling pathways in triple negative breast cancer cells by a novel derivative of Taiwanin A. (IF=5.579)
Chiang EI*, Kuo YH, Chao CY, Rodriguez RL, Chou PY, Tsai SY, Pai MH, Tang FY.
Mol Cancer Ther. 2016 Dec 12. pii: molcanther.0011.2016. [Epub ahead of print]
PMID: 27956520
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Wang YC, Wu MT, Lin YJ, Tang FY, Ko HA, Chiang EP*.
J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S148-50. doi: 10.3177/jnsv.61.S148.
PMID: 26598833
Lower serum folate is associated with development and invasiveness of gastric cancer.
Lee TY, Chiang EP*, Shih YT, Lane HY, Lin JT, Wu CY.
World J Gastroenterol. 2014 Aug 28;20(32):11313-20. doi: 10.3748/wjg.v20.i32.11313.
PMID: 25170216
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways.
Chiang EP*, Tsai SY, Kuo YH, Pai MH, Chiu HL, Rodriguez RL, Tang FY.
PLoS One. 2014 Jun 24;9(6):e99631. doi: 10.1371/journal.pone.0099631.
PMID: 24960186
Eicosapentaenoic acid induces neovasculogenesis in human endothelial progenitor cells by modulating c-kit protein and PI3-K/Akt/eNOS signaling pathways. (IF 4.668)
Chiu SC, Chiang EP*, Tsai SY, Wang FY, Pai MH, Syu JN, Cheng CC, Rodriguez RL, Tang FY.
J Nutr Biochem. 2014 Sep;25(9):934-45. doi: 10.1016/j.jnutbio.2014.04.007.
PMID: 24927915
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Wang YC, Lin WL, Lin YJ, Tang FY, Chen YM, Chiang EP*.
Int J Cancer. 2014 Feb 15;134(4):799-810. doi: 10.1002/ijc.28420.
PMID: 23922098
Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism. (IF=6.703)
Chang HY, Tang FY, Chen DY, Chih HM, Huang ST, Cheng HD, Lan JL, Chiang EP*.
Am J Clin Nutr. 2013 Dec;98(6):1440-9. doi: 10.3945/ajcn.113.064477.
PMID: 24153347
Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways.
Chiang EP*, Chiu SC, Pai MH, Wang YC, Wang FY, Kuo YH, Tang FY.
J Agric Food Chem. 2013 May 22;61(20):4839-49. doi: 10.1021/jf304951p.
PMID: 23663050
Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo.
Wang YC and Chiang EP* (*Corresponding author).
Molecular Medicine Accepted. (2010 SCI IF  5.908 Medicine Research & Experimental top 10%) NSC97-2320-B-005-008-MY3 and NSC100-2628-B-005-002-MY4 
Serine Hydroxymethyltransferase anchors the de novo thymidylate synthesis pathway to the nuclear lamina for DNA synthesis.
Anderson D, Woeller C, Chiang EP, Shane B, Stover PJ.
Journal of Biological Biochemistry (2010 SCI  5.328, Biochemistry & Molecular Biology 50/286) 20
Consumption of high-fat diet induces tumor progression and epithelialmesenchymal transition of colorectal cancer in a mouse xenograft model.
Tang FY, Pai MH, Chiang EP.
Journal of Nutritional Biochemistry (2010 SCI IF  4.538 Nutrition& Dietetic top 7%, Top 5) 2012 Jan 3. [Epub ahead of print]
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.
Wang YC, Chen YM, Lin YJ, Liu SP, Chiang EP* (*Corresponding author).
Molecular Medicine (SCI 2010 IF  5.908 Medicine Research & Experimental Top 10%). NSC97-2320-B-005-008-MY3
Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expressions in patients with and without methotrexate treatment
Chen DR, Chih HM, Lan JL, Chang HY, Chen WW, Chiang EP*(Corresponding author).
BMC Medicine. 2011 Jan 13;9:4. (SCI 2010 IF  5.75 Medicine, General & Internal Top 7%) DOH 97-TD-D-113-97011
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation.
Wang YC, Tang FY, Chen SY, Chen YM, Chiang EP* (*Corresponding author).
Journal of Nutrition 2011 May;141(5):777-82. (SCI 2010 IF  4.295 Nutrition & Dietetic 11%). NSC97-2320-B-005-008-MY3
Long-term prednisolone treatments increase bioactive vitamin B6 synthesis in vivo.
Chang HY, Tzen JT, Lin SJ, Wu, YT, Chiang EP*(Corresponding author).
Journal of Pharmacology & Experimental Therapeutics 2011 Apr;337(1):102-9. (SCI 2010 IF  4.017 Pharmacology & Pharmacy 15%) NSC97-2320-B-005-008-MY3 and DOH 97-TD-D-113-97011
Low-dose methotrexate treatment is associated with increased total cholesterol and HDL-cholesterol in blood: a pilot study
Chih HM, Chang HY, Chen WW, Chen DR, Lan JL, Chiang EP*(Corresponding author).
Nutrition Science Journal 2010.Dec.  DOH 97-TD-D-113-97011
S-Allylcysteine inhibits tumor progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer.
Pai MH, Kuo YH, Chiang EP, Tang FY.
British Journal of Nutrition. (SCI 2010 IF 3.072) 2011 Oct 20:1-11.



Chuang YC, Tang FY, Liao JW, Chuang CH, Jong TT, Chen SS, Tsai CH, Chiang EP* (Corresponding author). Isatis indigotica induces hepatocellular cancer cell death via caspase- independent, apoptosis inducing factor translocation apoptotic pathway in vitro and in vivo. Integrative Cancer Therapy. 2011 Mar 7. [Epub ahead of print] (Integrative & Complementary Medicine ) NSC93-2317-B005-013  (PMID:21382959)

Tang FY*, Chiang EP* (corresponding author), and Pai MH. Consumption of S-allylcysteine inhibits the growth of human non-small cell lung carcinoma in a mouse xenograft model. Journal of Agricultural and Food Chemistry. 2010 Sep 24. [Epub ahead of print] (SCI 2009 IF 2.816 Agriculture Multidisciplinary 4.5%, Top 2) Supported in part by NSC97-2321-B-005-005 (PMID:20866043)


Chiang EP*(Corresponding author), Wang YC, Chen WW, Tang FY. Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation. Journal of Clinical Endocrinology & Metabolism 2009 Mar;94(3):1017-25. (2010 SCI IF  6.495 Endocrinology & Metabolism 11%) supported by NSC97-2320-B-005-008-MY3) (cited by Cell Metabolism.   (PMID:19088160)

Tang FY, Chiang EP and Chung JG, Lee HZ, Hsu CY. S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer (NSC 93-2320-B030-003) Journal of Nutritional Biochemistry (2010 SCI IF 4.538 Nutrition& Dietetic Top 5) 2009Dec;20 (12) : 1013-20.  (PMID:19088160)

Sohn KJ, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang YJ, Cho RC, Yates Z, Lucock M, Chiang EP, Austin RC, Choi SW, Laird PW, Kim YI. The methylenetetrahydrofolate reductase C677T mutation induces cell specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification.  International Journal of Cancer. (2010 SCI IF 4.926, Oncology 32/184). 2009 May 1;124(9):1999-2005. Supported in part by NSC95-2320-B-005-008-MY3 and DOH 96-TD-D-113-039  (PMID:19123462)


Chiang EP*(Corresponding author), Wang YC, Tang FY. Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate dependent remethylation in human transformed lymphoblasts.  NSC-93-2313-B-005-083 Leukemia (2010 SCI IF 8.966, Hematology Top 4; Oncology Top 5%) 2007 Apr;21(4):651-8.  (PMID:17301815)

Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Hwang SF, Chen YM. Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver Hepatology (2010 SCI IF 10.885 Gastroenterology & Hepatology Top 2, 2/71) 2007 Oct 15;46(5):1413-1425 NSC95-3112-B-010-010 (PMID:17937387)

Tang FY, Chiang EP. Resveratrol inhibits heregulin-beta1 mediated matrix metalloproteinase 9 expression and cell invasion in human breast cancer cells. NSC 93-2320-B030-003 Journal of Nutritional Biochemistry (2010 SCI IF 4.538 Nutrition& Dietetic Top 5). 2008 19: 287-294.  (PMID:17651959)

Wu CY, Wu MS, Chiang EP, Wu, CC, Chen YJ, Chen CJ, Chi NH, Chen GH, Lin JT. Elevated plasma osteopontin associated with gastric cancer development, invasion and survival. Gut (2010 SCI IF 10.614, Gastroenterology & Hepatology Top 3) 2007 Jun;56(6):782-9.  (PMID:17148500)

Wu CY, Wu MS, Chiang EP, Chen YJ, Chen CJ, Chi NH, Shih YT, Chen GH, Lin JT. Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution. Clinical Cancer Research (2010 SCI IF 7.338, Oncology 16/184) 2007 Apr 1;13(7):2054-60   (PMID:17404086)

Tang FY, Chiang EP, Shih CJ. Green tea catechin inhibits ephrin-A1-mediated cell migration and angiogenesis of human umbilical vein endothelial cells Journal of Nutritional Biochemistry (2010 SCI IF 4.538 Nutrition& Dietetic Top 5). 18(6) 391-399 Supported byNSC-93-2320-B-030-003 (PMID:17049832)


Anguera MC, Field MS, Perry C, Ghandour H, Chiang EP, Selhub J, Shane B, Stover PJ. Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. Journal of Biological Chemistry (2010 SCI IF  5.328, Biochemistry & Molecular Biology 50/286) 2006 Jul.7;281(27):18335-42. (cited by Science in 2010)   (PMID:16627483)


Stempak JM, Sohn KJ, Chiang EP, Shane B, Kim YI. Cell and stage of transformation -specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model Carcinogenesis (2010 SCI IF  5.402 Oncology 27/184) 2005 May;26(5):981-90. Supported in part by NSC-93-2320- B-005-006(PMID:15695236)

Chiang EP* (Corresponding author), Smith DE, Selhub J, Dallal G, Wang YC, and Roubenoff R. Inflammation causes tissue specific depletion of vitamin B6. Arthritis Research & Therapy (2010 SCI IF  4.357) 2005 Sep 7:1254-1262 Supported in part by NSC 94-2320-B005-009 Highlighted article (PMID:16277678)

Chiang EP*(Corresponding author), Selhub J, Bagley P, Dallal G, and Roubenoff R. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Research & Therapy (2010 SCI IF 4.357) 2005 Oct 7:1404-1411. NSC 94-2320-B005-009  Highlighted article (PMID:16277693)


Chiang EP*(Corresponding author), Bagley P, Selhub J, Nadeau M, and Roubenoff R. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. American Journal of Medicine (SCI 2010 IF  5.115 Medicine, General & Internal Top 9%)  (PMID:12681455)

Chiang EP*(Corresponding author), Roubenoff R, Selhub J, Bagley PJ. Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status Journal of Nutrition 133:1056-1059 (SCI 2010 IF 4.295 Nutrition & Dietetics 11%  (PMID:12672918)


Herbig K, Chiang E-P, Lee LR, Hills J, Shane B and Stover PJ. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate–dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. Journal of Biological Chemistry (2010 SCI  5.328, Biochemistry & Molecular Biology 50/286) 2002 Oct. 277 (41):38381-9.  (PMID:12161434)


National Chung Hsing University
Food Science and Biotechnology

All Right Revered. Last Update March 2015